DNA polymerase beta · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P06766. Use UniProt P06766 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06766 as the stable identity anchor, then attach disease evidence before program review.
DNA polymerase beta
Review this target as DNA polymerase beta, mapped to UniProt P06766. Sequence length is 335 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA polymerase beta as ChEMBL target CHEMBL4343, mapped to UniProt P06766. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA polymerase beta is the right protein anchor across sources, using UniProt P06766 as the stable mapping.
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| Preferred Name | DNA polymerase beta |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P06766 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA polymerase beta |
| UniProt Accession | P06766 |
| Component Type | Protein |
| Sequence Length | 335 aa |
DNA polymerase beta
Review this target as DNA polymerase beta, mapped to UniProt P06766. Sequence length is 335 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL448072 | 5.92 | IC50 | 1200.0 | Preclinical |
| CHEMBL453751 | 5.7 | IC50 | 2000.0 | Preclinical |
| CHEMBL479472 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL465365 | 5.57 | IC50 | 2700.0 | Preclinical |
| CHEMBL519411 | 5.55 | Ki | 2800.0 | Preclinical |
| CHEMBL494656 | 5.54 | IC50 | 2900.0 | Preclinical |
| CHEMBL517522 | 5.5 | IC50 | 3200.0 | Preclinical |
| CHEMBL168 | 5.43 | IC50 | 3700.0 | Preclinical |
| CHEMBL3138225 | 5.33 | Ki | 4700.0 | Preclinical |
| CHEMBL169 | 5.32 | IC50 | 4800.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 74 | 46 | 4.9 |
| assay format | 2 | 1 | 4.5 |
| cell-based format | 2 | 4 | 4.7 |