Cyclin-G-associated kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O14976. Use UniProt O14976 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14976 as the stable identity anchor, then attach disease evidence before program review.
Cyclin-G-associated kinase
Review this target as Cyclin-G-associated kinase, mapped to UniProt O14976. Sequence length is 1311 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cyclin-G-associated kinase as ChEMBL target CHEMBL4355, mapped to UniProt O14976. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cyclin-G-associated kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14976 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cyclin-G-associated kinase |
| UniProt Accession | O14976 |
| Component Type | Protein |
| Sequence Length | 1311 aa |
Cyclin-G-associated kinase
Review this target as Cyclin-G-associated kinase, mapped to UniProt O14976. Sequence length is 1311 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4531690 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL3545396 | 9.52 | Kd | 0.3 | Clinical |
| CHEMBL81073 | 9.38 | Kd | 0.42 | Preclinical |
| CHEMBL5415503 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL1287853 | 9.0 | IC50 | 1.0 | Approved |
| CHEMBL1287853 | 8.96 | Kd | 1.1 | Approved |
| CHEMBL288441 | 8.89 | Kd | 1.3 | Approved |
| CHEMBL607707 | 8.82 | Kd | 1.5 | Clinical |
| CHEMBL4797973 | 8.82 | Ki | 1.5 | Preclinical |
| CHEMBL4443342 | 8.72 | Kd | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 170 | 139 | 7.0 |
| assay format | 41 | 120 | 7.0 |
| cell-based format | 25 | 57 | 6.8 |
| subcellular format | 16 | 59 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 0 | — |
| assay format | 1 | 1 | 6.8 |