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Evidence Snapshot

Dual specificity tyrosine-phosphorylation-regulated kinase 2

CHEMBL4376 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:26Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4376
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dual specificity tyrosine-phosphorylation-regulated kinase 2 as ChEMBL target CHEMBL4376, mapped to UniProt Q92630. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dual specificity tyrosine-phosphorylation-regulated kinase 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4376
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q92630
Dual specificity tyrosine-phosphorylation-regulated kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Dual specificity tyrosine-phosphorylation-regulated kinase 2 matters

As of 2026-09-14

Dual specificity tyrosine-phosphorylation-regulated kinase 2 is reviewed as Dual specificity tyrosine-phosphorylation-regulated kinase 2 (UniProt Q92630); the current evidence base includes 6 approved drugs, 1783 compounds, and 347 assays, with lead potency reaching pChEMBL 9.2.

Protein context
Dual specificity tyrosine-phosphorylation-regulated kinase 2

Dual specificity tyrosine-phosphorylation-regulated kinase 2 Sequence length is 601 aa.

Review this target as Dual specificity tyrosine-phosphorylation-regulated kinase 2, mapped to UniProt Q92630. Sequence length is 601 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q92630 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 6 approved drugs, 1783 compounds, and 347 assays for this target. The dominant activity type is IC50. CHEMBL5289179 is the current potency anchor at pChEMBL 9.2.

Use CHEMBL5289179 as the tractability anchor when discussing potency (pChEMBL 9.2).

Activity source · ChEMBL 36 via Core Engine
6 approved pChEMBL 9.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Dual specificity tyrosine-phosphorylation-regulated kinase 2 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q92630, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1783
Total Compounds
347
Total Assays
6
Approved Drugs
IC50: 791.0, KI: 6.0, KD: 91.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5289179
 9.2 IC50 —
No preferred name
CHEMBL5084504
 9.0 IC50 —
No preferred name
CHEMBL4784318
 8.7 IC50 —
No preferred name
CHEMBL5090676
 8.7 IC50 —
No preferred name
CHEMBL140
 8.6 IC50 Clinical

Approved Drugs

Structure Compound First Approval
ABEMACICLIB
CHEMBL3301610
 2017
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:26Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4376