Vacuolar-type proton translocating pyrophosphatase 1 · SINGLE PROTEIN · Trypanosoma brucei
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As of 2026-09-14Protein identity stays anchored to UniProt Q8MTZ4. Use UniProt Q8MTZ4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8MTZ4 as the stable identity anchor, then attach disease evidence before program review.
H(+)-exporting diphosphatase
Review this target as Vacuolar-type proton translocating pyrophosphatase 1, mapped to UniProt Q8MTZ4. ChEMBL maps the protein component as H(+)-exporting diphosphatase. Sequence length is 826 aa.
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This review treats Vacuolar-type proton translocating pyrophosphatase 1 as ChEMBL target CHEMBL4386, mapped to UniProt Q8MTZ4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Vacuolar-type proton translocating pyrophosphatase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei |
| UniProt | Q8MTZ4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | H(+)-exporting diphosphatase |
| UniProt Accession | Q8MTZ4 |
| Component Type | Protein |
| Sequence Length | 826 aa |
H(+)-exporting diphosphatase
Review this target as Vacuolar-type proton translocating pyrophosphatase 1, mapped to UniProt Q8MTZ4. ChEMBL maps the protein component as H(+)-exporting diphosphatase. Sequence length is 826 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL414849 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL54925 | 5.62 | IC50 | 2400.0 | Preclinical |
| CHEMBL370662 | 5.42 | IC50 | 3800.0 | Preclinical |
| CHEMBL191613 | 5.37 | IC50 | 4300.0 | Preclinical |
| CHEMBL55371 | 5.37 | IC50 | 4300.0 | Preclinical |
| CHEMBL102478 | 5.26 | IC50 | 5500.0 | Preclinical |
| CHEMBL196254 | 5.21 | IC50 | 6200.0 | Preclinical |
| CHEMBL450938 | 5.19 | IC50 | 6500.0 | Preclinical |
| CHEMBL195034 | 5.12 | IC50 | 7500.0 | Preclinical |
| CHEMBL199206 | 5.1 | IC50 | 8000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 81 | 4.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |