Endothelin receptor type B · SINGLE PROTEIN · Bos taurus
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As of 2026-09-13Protein identity stays anchored to UniProt P28088. Use UniProt P28088 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28088 as the stable identity anchor, then attach disease evidence before program review.
Endothelin receptor type B
Review this target as Endothelin receptor type B, mapped to UniProt P28088. Sequence length is 441 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Endothelin receptor type B as ChEMBL target CHEMBL4401, mapped to UniProt P28088. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Endothelin receptor type B is the right protein anchor across sources, using UniProt P28088 as the stable mapping.
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| Preferred Name | Endothelin receptor type B |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P28088 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Endothelin receptor type B |
| UniProt Accession | P28088 |
| Component Type | Protein |
| Sequence Length | 441 aa |
Endothelin receptor type B
Review this target as Endothelin receptor type B, mapped to UniProt P28088. Sequence length is 441 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL438733 | 10.03 | IC50 | 0.093 | Preclinical |
| CHEMBL437472 | 9.92 | IC50 | 0.12 | Clinical |
| CHEMBL427748 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL1790962 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL263855 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL2373292 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL1790963 | 9.48 | IC50 | 0.33 | Preclinical |
| CHEMBL2373291 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL411171 | 9.35 | IC50 | 0.45 | Preclinical |
| CHEMBL414047 | 8.6 | IC50 | 2.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 19 | 7.1 |
| cell membrane format | 1 | 8 | 9.7 |