Plasmepsin II · SINGLE PROTEIN · Plasmodium falciparum
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P46925. Use UniProt P46925 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P46925 as the stable identity anchor, then attach disease evidence before program review.
Plasmepsin II
Review this target as Plasmepsin II, mapped to UniProt P46925. Sequence length is 453 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Plasmepsin II as ChEMBL target CHEMBL4414, mapped to UniProt P46925. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Plasmepsin II is the right protein anchor across sources, using UniProt P46925 as the stable mapping.
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| Preferred Name | Plasmepsin II |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
| UniProt | P46925 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Plasmepsin II |
| UniProt Accession | P46925 |
| Component Type | Protein |
| Sequence Length | 453 aa |
Plasmepsin II
Review this target as Plasmepsin II, mapped to UniProt P46925. Sequence length is 453 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1208799 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL1209499 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL257594 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL411559 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL1213687 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL296588 | 9.38 | IC50 | 0.42 | Clinical |
| CHEMBL112598 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL231522 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL113208 | 9.25 | Ki | 0.56 | Preclinical |
| CHEMBL1213687 | 9.23 | IC50 | 0.59 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 62 | 496 | 6.8 |
| assay format | 13 | 97 | 7.3 |
| cell-based format | 1 | 0 | — |