Steroid 17-alpha-hydroxylase/17,20 lyase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P11715. Use UniProt P11715 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11715 as the stable identity anchor, then attach disease evidence before program review.
Steroid 17-alpha-hydroxylase/17,20 lyase
Review this target as Steroid 17-alpha-hydroxylase/17,20 lyase, mapped to UniProt P11715. Sequence length is 507 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Steroid 17-alpha-hydroxylase/17,20 lyase as ChEMBL target CHEMBL4430, mapped to UniProt P11715. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Steroid 17-alpha-hydroxylase/17,20 lyase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P11715 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Steroid 17-alpha-hydroxylase/17,20 lyase |
| UniProt Accession | P11715 |
| Component Type | Protein |
| Sequence Length | 507 aa |
Steroid 17-alpha-hydroxylase/17,20 lyase
Review this target as Steroid 17-alpha-hydroxylase/17,20 lyase, mapped to UniProt P11715. Sequence length is 507 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3677924 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL3639767 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL2111947 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL3677955 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3677931 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL1682893 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL2111951 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL2112517 | 8.11 | IC50 | 7.7 | Preclinical |
| CHEMBL310336 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL1766170 | 8.08 | IC50 | 8.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 35 | 126 | 6.0 |
| single protein format | 19 | 45 | 5.8 |
| microsome format | 3 | 41 | 7.4 |
| cell-based format | 2 | 4 | 8.6 |
| tissue-based format | 2 | 4 | 4.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| microsome format | 8 | 9 | 6.2 |
| single protein format | 1 | 1 | 6.0 |
| tissue-based format | 1 | 1 | 6.3 |