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Target Snapshot

CHEMBL4434621 Target Snapshot

Ebolavirus · ORGANISM · Ebolavirus

Back to Search Search this target Browse approvals Evidence Card
582Compounds
207Assays
18Approved Drugs
702.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ebolavirus as ChEMBL target CHEMBL4434621. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ebolavirus
ORGANISM · Ebolavirus
As of 2026-09-14
ChEMBL target ID
CHEMBL4434621
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ebolavirus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameEbolavirus
Target TypeORGANISM
OrganismEbolavirus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEbolavirus
UniProt AccessionN/A

Ebolavirus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Ebolavirus.

Review nameEbolavirus
OrganismEbolavirus
Clinical Profile

Clinical Phase Distribution

18
Approved
2
Phase III
7
Phase II
3
Phase I
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC50336.0
EC50366.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4743491 10.4 IC50 0.04 Preclinical
CHEMBL4755358 10.4 IC50 0.04 Preclinical
CHEMBL5181012 10.4 IC50 0.04 Preclinical
CHEMBL5185113 10.4 IC50 0.04 Preclinical
CHEMBL5190923 10.4 IC50 0.04 Preclinical
CHEMBL5198546 10.4 IC50 0.04 Preclinical
CHEMBL91704 9.44 IC50 0.36 Clinical
CHEMBL4205398 8.96 IC50 1.1 Preclinical
CHEMBL4217113 8.85 IC50 1.4 Preclinical
CHEMBL5596937 8.7 EC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

130
5.0
129
5.5
91
6.0
71
6.5
56
7.0
23
7.5
10
8.0
4
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

REMDESIVIR
CHEMBL4065616
Approved 2020
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
TOREMIFENE
CHEMBL1655
Approved 1996
Properties Compare Identifier
Assay Landscape

Assay Landscape

207
Total Assays
491
Tested Compounds
1
Assay Types
Functional — 207 assays, 491 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 159 259 6.0
cell-based format 29 128 5.6
assay format 19 104 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine