Skip to main content
Evidence Snapshot

Vitamin K-dependent protein C

CHEMBL4444 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:11Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4444
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Vitamin K-dependent protein C as ChEMBL target CHEMBL4444, mapped to UniProt P04070. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Vitamin K-dependent protein C
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4444
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P04070
Vitamin K-dependent protein C
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Vitamin K-dependent protein C matters

As of 2026-09-13

Vitamin K-dependent protein C is reviewed as Vitamin K-dependent protein C (UniProt P04070); Vitamin K-dependent protein C shows approved-linked disease relevance led by deep vein thrombosis. 4 more disease programs remain visible in the same review block.; 1 linked drug keep this evidence frame grounded.; the current evidence base includes 1 approved drug, 411 compounds, and 117 assays, with lead potency reaching pChEMBL 9.3.

Disease context
deep vein thrombosis

Vitamin K-dependent protein C shows approved-linked disease relevance led by deep vein thrombosis. 4 more disease programs remain visible in the same review block. 1 linked drug keep the rationale reviewable. 4 additional disease programs remain visible in the same card. Linked drugs include PROTEIN C CONCENTRATE (HUMAN).

Start review with deep vein thrombosis because it currently carries approved-linked support. Linked drugs include PROTEIN C CONCENTRATE (HUMAN). This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 1 linked drug
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 411 compounds, and 117 assays for this target. The dominant activity type is KI. CHEMBL4471466 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL4471466 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 9.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Vitamin K-dependent protein C matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P04070, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why deep vein thrombosis is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

411
Total Compounds
117
Total Assays
1
Approved Drugs
IC50: 161.0, KI: 228.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4471466
 9.3 Ki —
No preferred name
CHEMBL2016865
 9.2 Ki —
No preferred name
CHEMBL4638245
 8.7 Ki —
No preferred name
CHEMBL2016866
 8.3 Ki —
No preferred name
CHEMBL3660179
 7.6 Ki —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:11Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4444