NAD-dependent protein deacetylase sirtuin-3, mitochondrial · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q9NTG7. Use UniProt Q9NTG7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NTG7 as the stable identity anchor, then attach disease evidence before program review.
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Review this target as NAD-dependent protein deacetylase sirtuin-3, mitochondrial, mapped to UniProt Q9NTG7. Sequence length is 399 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent protein deacetylase sirtuin-3, mitochondrial as ChEMBL target CHEMBL4461, mapped to UniProt Q9NTG7. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether NAD-dependent protein deacetylase sirtuin-3, mitochondrial is the right protein anchor across sources, using UniProt Q9NTG7 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NTG7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
| UniProt Accession | Q9NTG7 |
| Component Type | Protein |
| Sequence Length | 399 aa |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Review this target as NAD-dependent protein deacetylase sirtuin-3, mitochondrial, mapped to UniProt Q9NTG7. Sequence length is 399 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2332041 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL2332039 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL2332037 | 8.31 | IC50 | 4.9 | Preclinical |
| CHEMBL5614132 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL2338810 | 8.14 | IC50 | 7.2 | Preclinical |
| CHEMBL2332043 | 8.12 | IC50 | 7.6 | Preclinical |
| CHEMBL2332042 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL2332040 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL2332038 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL2338813 | 7.55 | IC50 | 28.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 137 | 159 | 5.4 |
| assay format | 71 | 134 | 5.7 |
| cell-based format | 48 | 29 | 5.4 |
| subcellular format | 4 | 0 | — |
| mitochondrion format | 2 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 6 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 0 | — |
| assay format | 1 | 0 | — |