NAD-dependent protein deacetylase sirtuin-2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q8IXJ6. Use UniProt Q8IXJ6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8IXJ6 as the stable identity anchor, then attach disease evidence before program review.
NAD-dependent protein deacetylase sirtuin-2
Review this target as NAD-dependent protein deacetylase sirtuin-2, mapped to UniProt Q8IXJ6. Sequence length is 389 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NAD-dependent protein deacetylase sirtuin-2 as ChEMBL target CHEMBL4462, mapped to UniProt Q8IXJ6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NAD-dependent protein deacetylase sirtuin-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8IXJ6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NAD-dependent protein deacetylase sirtuin-2 |
| UniProt Accession | Q8IXJ6 |
| Component Type | Protein |
| Sequence Length | 389 aa |
NAD-dependent protein deacetylase sirtuin-2
Review this target as NAD-dependent protein deacetylase sirtuin-2, mapped to UniProt Q8IXJ6. Sequence length is 389 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3769432 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL2338810 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL2332037 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL2332041 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL2332039 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL5614132 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL3779989 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL2332042 | 8.36 | IC50 | 4.4 | Preclinical |
| CHEMBL2332040 | 8.32 | IC50 | 4.8 | Preclinical |
| CHEMBL2332044 | 8.27 | IC50 | 5.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 317 | 646 | 5.4 |
| assay format | 116 | 367 | 5.7 |
| cell-based format | 94 | 42 | 5.6 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 12 | 11 | 5.0 |
| assay format | 2 | 0 | — |
| cell-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |