Sterol O-acyltransferase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q61263. Use UniProt Q61263 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q61263 as the stable identity anchor, then attach disease evidence before program review.
Sterol O-acyltransferase 1
Review this target as Sterol O-acyltransferase 1, mapped to UniProt Q61263. Sequence length is 540 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sterol O-acyltransferase 1 as ChEMBL target CHEMBL4464, mapped to UniProt Q61263. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sterol O-acyltransferase 1 is the right protein anchor across sources, using UniProt Q61263 as the stable mapping.
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| Preferred Name | Sterol O-acyltransferase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q61263 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sterol O-acyltransferase 1 |
| UniProt Accession | Q61263 |
| Component Type | Protein |
| Sequence Length | 540 aa |
Sterol O-acyltransferase 1
Review this target as Sterol O-acyltransferase 1, mapped to UniProt Q61263. Sequence length is 540 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4247249 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL300883 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL53728 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL4241747 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL4243015 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL4240947 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL4245998 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL52006 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL4248936 | 7.23 | IC50 | 59.0 | Preclinical |
| CHEMBL101309 | 7.22 | IC50 | 60.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 36 | 153 | 5.9 |
| organism-based format | 9 | 0 | — |
| single protein format | 2 | 0 | — |
| microsome format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 4 | 0 | — |
| assay format | 2 | 4 | 6.1 |
| tissue-based format | 2 | 0 | — |