Histamine H4 receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q91ZY1. Use UniProt Q91ZY1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q91ZY1 as the stable identity anchor, then attach disease evidence before program review.
Histamine H4 receptor
Review this target as Histamine H4 receptor, mapped to UniProt Q91ZY1. Sequence length is 391 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H4 receptor as ChEMBL target CHEMBL4468, mapped to UniProt Q91ZY1. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histamine H4 receptor is the right protein anchor across sources, using UniProt Q91ZY1 as the stable mapping.
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| Preferred Name | Histamine H4 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q91ZY1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H4 receptor |
| UniProt Accession | Q91ZY1 |
| Component Type | Protein |
| Sequence Length | 391 aa |
Histamine H4 receptor
Review this target as Histamine H4 receptor, mapped to UniProt Q91ZY1. Sequence length is 391 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4454158 | 10.3 | EC50 | 0.05012 | Preclinical |
| CHEMBL4443126 | 9.21 | EC50 | 0.6166 | Preclinical |
| CHEMBL4439142 | 9.19 | EC50 | 0.6457 | Preclinical |
| CHEMBL4543119 | 8.93 | EC50 | 1.175 | Preclinical |
| CHEMBL4445423 | 8.86 | EC50 | 1.38 | Preclinical |
| CHEMBL1079516 | 8.84 | Ki | 1.445 | Preclinical |
| CHEMBL523225 | 8.84 | Ki | 1.445 | Preclinical |
| CHEMBL592379 | 8.81 | Ki | 1.549 | Preclinical |
| CHEMBL4455324 | 8.75 | EC50 | 1.778 | Preclinical |
| CHEMBL129198 | 8.62 | Ki | 2.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 31 | 7.5 |
| single protein format | 11 | 20 | 7.7 |
| cell membrane format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 99 | 6.6 |
| assay format | 5 | 5 | 6.7 |
| single protein format | 2 | 4 | 5.1 |