Metabotropic glutamate receptor 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P23385. Use UniProt P23385 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P23385 as the stable identity anchor, then attach disease evidence before program review.
Metabotropic glutamate receptor 1
Review this target as Metabotropic glutamate receptor 1, mapped to UniProt P23385. Sequence length is 1199 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Metabotropic glutamate receptor 1 as ChEMBL target CHEMBL4477, mapped to UniProt P23385. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Metabotropic glutamate receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P23385 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Metabotropic glutamate receptor 1 |
| UniProt Accession | P23385 |
| Component Type | Protein |
| Sequence Length | 1199 aa |
Metabotropic glutamate receptor 1
Review this target as Metabotropic glutamate receptor 1, mapped to UniProt P23385. Sequence length is 1199 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL241327 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL1783868 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL236177 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL236994 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL1783869 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL1951662 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL235975 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL393923 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL235977 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL1783874 | 9.22 | Ki | 0.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 55 | 6 | 7.5 |
| single protein format | 37 | 102 | 7.1 |
| cell-based format | 23 | 54 | 6.1 |
| assay format | 12 | 4 | 5.1 |
| cell membrane format | 3 | 46 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 56 | 196 | 6.6 |
| assay format | 21 | 129 | 7.2 |
| single protein format | 7 | 4 | 5.8 |
| organism-based format | 1 | 0 | — |