Nitric oxide synthase, inducible · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Nitric oxide synthase, inducible shows clinical signal disease relevance led by migraine disorder. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P35228. Start with migraine disorder, then reuse UniProt P35228 as the stable protein anchor across project notes and exports.
Start with migraine disorder, then reuse UniProt P35228 as the stable protein anchor across project notes and exports.
Nitric oxide synthase, inducible shows clinical signal disease relevance led by migraine disorder. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with migraine disorder because it currently carries clinical signal support. Linked drugs include GW-274150. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNitric oxide synthase, inducible
Review this target as Nitric oxide synthase, inducible, mapped to UniProt P35228. Sequence length is 1153 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nitric oxide synthase, inducible as ChEMBL target CHEMBL4481, mapped to UniProt P35228. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Nitric oxide synthase, inducible is the right protein anchor across sources, using UniProt P35228 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why migraine disorder is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Nitric oxide synthase, inducible |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35228 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nitric oxide synthase, inducible |
| UniProt Accession | P35228 |
| Component Type | Protein |
| Sequence Length | 1153 aa |
Nitric oxide synthase, inducible
Review this target as Nitric oxide synthase, inducible, mapped to UniProt P35228. Sequence length is 1153 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Nitric oxide synthase, inducible shows clinical signal disease relevance led by migraine disorder. 2 more disease programs remain visible in the same review block.
Start review with migraine disorder because it currently carries clinical signal support. Linked drugs include GW-274150. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL220632 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL220880 | 9.89 | IC50 | 0.13 | Preclinical |
| CHEMBL1093059 | 9.7 | IC50 | 0.2 | Clinical |
| CHEMBL385324 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL385325 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL376733 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL376632 | 9.54 | IC50 | 0.29 | Preclinical |
| CHEMBL290548 | 9.42 | IC50 | 0.38 | Preclinical |
| CHEMBL427062 | 9.32 | IC50 | 0.48 | Preclinical |
| CHEMBL373623 | 9.32 | IC50 | 0.48 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 120 | 572 | 5.8 |
| cell-based format | 43 | 435 | 6.3 |
| assay format | 25 | 88 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 33 | 5.8 |
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 15 | 5.2 |