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Target Snapshot

CHEMBL4483255 Target Snapshot

MCF7/PTX · CELL-LINE · Homo sapiens

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8Compounds
41Assays
1Approved Drugs
8.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MCF7/PTX as ChEMBL target CHEMBL4483255. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MCF7/PTX
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4483255
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MCF7/PTX still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMCF7/PTX
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMCF7/PTX
UniProt AccessionN/A

MCF7/PTX

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MCF7/PTX.

Review nameMCF7/PTX
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4442478 5.54 IC50 2920.0 Preclinical
CHEMBL295316 5.46 IC50 3500.0 Preclinical
CHEMBL4469794 5.34 IC50 4540.0 Preclinical
CHEMBL4459091 5.26 IC50 5530.0 Preclinical
CHEMBL4555383 5.21 IC50 6110.0 Preclinical
CHEMBL4534246 4.82 IC50 15240.0 Preclinical
CHEMBL4581642 4.77 IC50 17080.0 Preclinical
CHEMBL428647 4.26 IC50 54800.0 Approved
Distribution

pChEMBL Value Distribution

4
5.0
1
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

41
Total Assays
8
Tested Compounds
1
Assay Types
Functional — 41 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 41 8 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine