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Target Snapshot

CHEMBL4483264 Target Snapshot

NCM460 · CELL-LINE · Homo sapiens

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509Compounds
64Assays
5Approved Drugs
418.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCM460 as ChEMBL target CHEMBL4483264. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCM460
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4483264
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCM460 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCM460
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCM460
UniProt AccessionN/A

NCM460

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCM460.

Review nameNCM460
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC50396.0
EC5022.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5557975 10.15 IC50 0.07 Preclinical
CHEMBL4466320 10.0 IC50 0.1 Preclinical
CHEMBL4636420 9.7 IC50 0.2 Preclinical
CHEMBL4472466 9.7 IC50 0.2 Preclinical
CHEMBL5646855 9.62 IC50 0.24 Preclinical
CHEMBL5557688 9.4 IC50 0.4 Preclinical
CHEMBL5555325 9.22 IC50 0.6 Preclinical
CHEMBL5559818 8.55 IC50 2.8 Preclinical
CHEMBL5560250 8.48 IC50 3.3 Preclinical
CHEMBL5557704 8.22 IC50 6.0 Preclinical
Distribution

pChEMBL Value Distribution

29
5.0
8
5.5
1
6.0
1
6.5
0
7.0
1
7.5
3
8.0
1
8.5
2
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

64
Total Assays
114
Tested Compounds
3
Assay Types
Toxicity — 31 assays, 71 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 71 5.5
ADME — 20 assays, 114 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 114 4.8
Functional — 13 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 12 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine