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Target Snapshot

CHEMBL4483265 Target Snapshot

RCC4/VHL · CELL-LINE · Homo sapiens

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11Compounds
14Assays
1Approved Drugs
10.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RCC4/VHL as ChEMBL target CHEMBL4483265. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RCC4/VHL
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4483265
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RCC4/VHL still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameRCC4/VHL
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRCC4/VHL
UniProt AccessionN/A

RCC4/VHL

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as RCC4/VHL.

Review nameRCC4/VHL
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5010.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428647 7.22 IC50 60.0 Approved
CHEMBL4854240 6.17 IC50 680.0 Preclinical
CHEMBL4859691 6.02 IC50 960.0 Preclinical
CHEMBL4854960 5.75 IC50 1780.0 Preclinical
CHEMBL4862637 5.66 IC50 2200.0 Preclinical
CHEMBL565269 5.28 IC50 5300.0 Preclinical
CHEMBL4579523 4.91 IC50 12300.0 Preclinical
CHEMBL319244 4.54 IC50 29100.0 Preclinical
CHEMBL131678 4.0 IC50 99600.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
2
5.5
2
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
9
Tested Compounds
1
Assay Types
Functional — 14 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 9 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine