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Target Snapshot

CHEMBL4483285 Target Snapshot

OCI-Ly10 · CELL-LINE · Homo sapiens

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174Compounds
245Assays
4Approved Drugs
112.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats OCI-Ly10 as ChEMBL target CHEMBL4483285. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
OCI-Ly10
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4483285
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether OCI-Ly10 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameOCI-Ly10
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOCI-Ly10
UniProt AccessionN/A

OCI-Ly10

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as OCI-Ly10.

Review nameOCI-Ly10
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

IC50109.0
EC503.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1873475 9.52 IC50 0.3 Approved
CHEMBL3936761 9.46 IC50 0.35 Approved
CHEMBL4794328 8.74 IC50 1.8 Preclinical
CHEMBL5077961 8.7 IC50 2.0 Clinical
CHEMBL4786559 8.68 IC50 2.1 Preclinical
CHEMBL5403933 8.64 IC50 2.3 Preclinical
CHEMBL4876497 8.49 IC50 3.2 Preclinical
CHEMBL4856793 8.4 EC50 4.0 Preclinical
CHEMBL4862901 8.4 EC50 4.0 Preclinical
CHEMBL5091956 8.4 IC50 4.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
7
5.5
15
6.0
16
6.5
12
7.0
13
7.5
11
8.0
5
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZANUBRUTINIB
CHEMBL3936761
Approved 2019
Properties Compare Identifier
IDELALISIB
CHEMBL2216870
Approved 2014
Properties Compare Identifier
IBRUTINIB
CHEMBL1873475
Approved 2013
Properties Compare Identifier
Assay Landscape

Assay Landscape

245
Total Assays
93
Tested Compounds
1
Assay Types
Functional — 245 assays, 93 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 196 93 6.8
organism-based format 47 0 —
assay format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine