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Target Snapshot

CHEMBL4513128 Target Snapshot

KB/VJ300 · CELL-LINE · Homo sapiens

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41Compounds
11Assays
2Approved Drugs
71.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KB/VJ300 as ChEMBL target CHEMBL4513128. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KB/VJ300
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4513128
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KB/VJ300 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKB/VJ300
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKB/VJ300
UniProt AccessionN/A

KB/VJ300

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KB/VJ300.

Review nameKB/VJ300
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5071.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL6966 7.0 IC50 100.0 Approved
CHEMBL4449333 6.7 IC50 200.0 Preclinical
CHEMBL90555 6.1 IC50 800.0 Approved
CHEMBL4161622 6.05 IC50 900.0 Preclinical
CHEMBL4520068 5.89 IC50 1300.0 Preclinical
CHEMBL4087281 5.85 IC50 1400.0 Preclinical
CHEMBL4587015 5.82 IC50 1500.0 Preclinical
CHEMBL4552198 5.57 IC50 2700.0 Preclinical
CHEMBL4435139 5.54 IC50 2900.0 Preclinical
CHEMBL4580115 5.54 IC50 2900.0 Preclinical
Distribution

pChEMBL Value Distribution

34
5.0
8
5.5
4
6.0
1
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VERAPAMIL
CHEMBL6966
Approved 1981
Properties Compare Identifier
VINCRISTINE
CHEMBL90555
Approved 1963
Properties Compare Identifier
Assay Landscape

Assay Landscape

11
Total Assays
28
Tested Compounds
1
Assay Types
Functional — 11 assays, 28 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 25 5.4
assay format 2 3 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine