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Evidence Snapshot

BMP-2-inducible protein kinase

CHEMBL4522 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:11Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4522
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BMP-2-inducible protein kinase as ChEMBL target CHEMBL4522, mapped to UniProt Q9NSY1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BMP-2-inducible protein kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4522
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9NSY1
BMP-2-inducible protein kinase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why BMP-2-inducible protein kinase matters

As of 2026-09-13

BMP-2-inducible protein kinase is reviewed as BMP-2-inducible protein kinase (UniProt Q9NSY1); the current evidence base includes 20 approved drugs, 595 compounds, and 168 assays, with lead potency reaching pChEMBL 9.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 20 approved drugs, 595 compounds, and 168 assays for this target. The dominant activity type is KD. CHEMBL4290597 is the current potency anchor at pChEMBL 9.7.

Use CHEMBL4290597 as the tractability anchor when discussing potency (pChEMBL 9.7).

Activity source · ChEMBL 36 via Core Engine
20 approved pChEMBL 9.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why BMP-2-inducible protein kinase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q9NSY1, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

595
Total Compounds
168
Total Assays
20
Approved Drugs
IC50: 47.0, KI: 23.0, KD: 398.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL4290597
 9.7 Kd —
No preferred name
CHEMBL3991929
 9.1 Kd —
No preferred name
CHEMBL388978
 9.0 Kd —
No preferred name
CHEMBL3752910
 8.9 Kd —
No preferred name
CHEMBL502835
 8.7 Kd Approved

Approved Drugs

Structure Compound First Approval
MOMELOTINIB
CHEMBL1078178
 2023
PACRITINIB
CHEMBL2035187
 2022
FEDRATINIB
CHEMBL1287853
 2019
GILTERITINIB
CHEMBL3301622
 2018
BARICITINIB
CHEMBL2105759
 2017
MIDOSTAURIN
CHEMBL608533
 2017
NINTEDANIB
CHEMBL502835
 2014
BOSUTINIB
CHEMBL288441
 2012
AXITINIB
CHEMBL1289926
 2012
RUXOLITINIB
CHEMBL1789941
 2011
CRIZOTINIB
CHEMBL601719
 2011
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:11Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4522