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Target Snapshot

CHEMBL4523 Target Snapshot

Serine/threonine-protein kinase pim-2 · SINGLE PROTEIN · Homo sapiens

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5,470Compounds
585Assays
3Approved Drugs
5,403.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9P1W9. Use UniProt Q9P1W9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9P1W9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase pim-2 as ChEMBL target CHEMBL4523, mapped to UniProt Q9P1W9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase pim-2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4523
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9P1W9
Serine/threonine-protein kinase pim-2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase pim-2 is the right protein anchor across sources, using UniProt Q9P1W9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSerine/threonine-protein kinase pim-2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9P1W9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase pim-2
UniProt AccessionQ9P1W9
Component TypeProtein
Sequence Length311 aa

Serine/threonine-protein kinase pim-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase pim-2, mapped to UniProt Q9P1W9. Sequence length is 311 aa.

Mapped IDQ9P1W9
Review nameSerine/threonine-protein kinase pim-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
5
Phase III
4
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC503,930.0
KI1,184.0
EC501.0
KD288.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3902148 10.92 IC50 0.012 Preclinical
CHEMBL3940091 10.92 IC50 0.012 Preclinical
CHEMBL3651966 10.74 IC50 0.018 Preclinical
CHEMBL3651966 10.74 Ki 0.018 Preclinical
CHEMBL4741714 10.74 IC50 0.018 Preclinical
CHEMBL3909351 10.7 IC50 0.02 Preclinical
CHEMBL2387464 10.49 Ki 0.032 Preclinical
CHEMBL3903686 10.45 IC50 0.0358 Preclinical
CHEMBL3949102 10.45 IC50 0.0354 Preclinical
CHEMBL2387465 10.43 Ki 0.037 Preclinical
Distribution

pChEMBL Value Distribution

143
5.0
177
5.5
686
6.0
380
6.5
446
7.0
430
7.5
422
8.0
354
8.5
174
9.0
105
9.5
pChEMBL
Assay Landscape

Assay Landscape

585
Total Assays
2,814
Tested Compounds
3
Assay Types
Binding — 554 assays, 2,814 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 458 2,471 7.3
assay format 72 309 7.9
cell-based format 23 33 6.2
subcellular format 1 1 7.4
Functional — 30 assays, 98 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 28 1 6.8
assay format 2 97 6.5
Toxicity — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 2 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine