Synaptojanin-2 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O15056. Use UniProt O15056 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15056 as the stable identity anchor, then attach disease evidence before program review.
Synaptojanin-2
Review this target as Synaptojanin-2, mapped to UniProt O15056. Sequence length is 1496 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Synaptojanin-2 as ChEMBL target CHEMBL4523129, mapped to UniProt O15056. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Synaptojanin-2 is the right protein anchor across sources, using UniProt O15056 as the stable mapping.
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| Preferred Name | Synaptojanin-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15056 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Synaptojanin-2 |
| UniProt Accession | O15056 |
| Component Type | Protein |
| Sequence Length | 1496 aa |
Synaptojanin-2
Review this target as Synaptojanin-2, mapped to UniProt O15056. Sequence length is 1496 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL509624 | 6.06 | IC50 | 874.0 | Preclinical |
| CHEMBL4472624 | 5.97 | IC50 | 1075.0 | Preclinical |
| CHEMBL4457836 | 5.91 | IC50 | 1240.0 | Preclinical |
| CHEMBL1201303 | 5.9 | IC50 | 1250.0 | Approved |
| CHEMBL4514986 | 5.78 | IC50 | 1670.0 | Preclinical |
| CHEMBL4456090 | 5.73 | IC50 | 1870.0 | Preclinical |
| CHEMBL4574176 | 5.73 | IC50 | 1870.0 | Preclinical |
| CHEMBL4465983 | 5.7 | IC50 | 1980.0 | Preclinical |
| CHEMBL4469371 | 5.7 | IC50 | 1980.0 | Preclinical |
| CHEMBL4575159 | 5.7 | IC50 | 1980.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 31 | 5.5 |