Use UniProt O35543 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4523131 Target Snapshot
Hematopoietic prostaglandin D synthase · SINGLE PROTEIN · Rattus norvegicus
Research home keeps recent targets
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Switch target
Move to another high-traffic target or paste a specific ChEMBL target ID.
Frame the target before identity details
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt O35543. Use UniProt O35543 as the stable identity anchor, then attach disease evidence before program review.
Hematopoietic prostaglandin D synthase
Review this target as Hematopoietic prostaglandin D synthase, mapped to UniProt O35543. Sequence length is 199 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hematopoietic prostaglandin D synthase as ChEMBL target CHEMBL4523131, mapped to UniProt O35543. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Start with the right source
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Hematopoietic prostaglandin D synthase is the right protein anchor across sources, using UniProt O35543 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardBasic Information
Verify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Hematopoietic prostaglandin D synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | O35543 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hematopoietic prostaglandin D synthase |
| UniProt Accession | O35543 |
| Component Type | Protein |
| Sequence Length | 199 aa |
Hematopoietic prostaglandin D synthase
How to read this target
Review this target as Hematopoietic prostaglandin D synthase, mapped to UniProt O35543. Sequence length is 199 aa.
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5279371 | 8.43 | EC50 | 3.7 | Preclinical |
| CHEMBL5267588 | 8.42 | EC50 | 3.8 | Preclinical |
| CHEMBL5272869 | 8.41 | EC50 | 3.9 | Preclinical |
| CHEMBL5289730 | 8.41 | EC50 | 3.9 | Preclinical |
| CHEMBL5278680 | 8.33 | EC50 | 4.7 | Preclinical |
| CHEMBL5269778 | 8.28 | EC50 | 5.2 | Preclinical |
| CHEMBL5282861 | 7.96 | EC50 | 11.0 | Preclinical |
| CHEMBL5266142 | 7.85 | EC50 | 14.0 | Preclinical |
| CHEMBL5285125 | 7.85 | EC50 | 14.0 | Preclinical |
| CHEMBL5277213 | 7.66 | EC50 | 22.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 3 assays, 72 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 72 | 6.7 |