Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P10515. Use UniProt P10515 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P10515 as the stable identity anchor, then attach disease evidence before program review.
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Review this target as Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, mapped to UniProt P10515. Sequence length is 647 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial as ChEMBL target CHEMBL4523180, mapped to UniProt P10515. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10515 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| UniProt Accession | P10515 |
| Component Type | Protein |
| Sequence Length | 647 aa |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Review this target as Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, mapped to UniProt P10515. Sequence length is 647 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5653589 | 7.26 | Kd | 54.52 | Preclinical |
| CHEMBL1237210 | 6.24 | Kd | 578.0 | Preclinical |
| CHEMBL3752910 | 5.59 | Kd | 2551.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 3 | 6.4 |
| cell-based format | 1 | 0 | — |