Interleukin-1 receptor antagonist protein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P18510. Use UniProt P18510 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18510 as the stable identity anchor, then attach disease evidence before program review.
Interleukin-1 receptor antagonist protein
Review this target as Interleukin-1 receptor antagonist protein, mapped to UniProt P18510. Sequence length is 177 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Interleukin-1 receptor antagonist protein as ChEMBL target CHEMBL4523191, mapped to UniProt P18510. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Interleukin-1 receptor antagonist protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P18510 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-1 receptor antagonist protein |
| UniProt Accession | P18510 |
| Component Type | Protein |
| Sequence Length | 177 aa |
Interleukin-1 receptor antagonist protein
Review this target as Interleukin-1 receptor antagonist protein, mapped to UniProt P18510. Sequence length is 177 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4101200 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5517929 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1277623 | 8.3 | IC50 | 5.012 | Preclinical |
| CHEMBL5191661 | 8.19 | IC50 | 6.5 | Preclinical |
| CHEMBL4455644 | 8.11 | IC50 | 7.7 | Preclinical |
| CHEMBL1277623 | 7.96 | Ki | 10.9 | Preclinical |
| CHEMBL5209483 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL5195885 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL4762305 | 7.62 | Ki | 23.7 | Preclinical |
| CHEMBL3416733 | 7.52 | IC50 | 30.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 15 | 52 | 6.0 |
| single protein format | 5 | 15 | 7.0 |