Aquaporin-1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P29972. Use UniProt P29972 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29972 as the stable identity anchor, then attach disease evidence before program review.
Aquaporin-1
Review this target as Aquaporin-1, mapped to UniProt P29972. Sequence length is 269 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aquaporin-1 as ChEMBL target CHEMBL4523210, mapped to UniProt P29972. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Aquaporin-1 is the right protein anchor across sources, using UniProt P29972 as the stable mapping.
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| Preferred Name | Aquaporin-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P29972 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aquaporin-1 |
| UniProt Accession | P29972 |
| Component Type | Protein |
| Sequence Length | 269 aa |
Aquaporin-1
Review this target as Aquaporin-1, mapped to UniProt P29972. Sequence length is 269 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL195380 | 5.57 | IC50 | 2700.0 | Preclinical |
| CHEMBL5268096 | 5.48 | EC50 | 3300.0 | Preclinical |
| CHEMBL5280011 | 5.24 | IC50 | 5800.0 | Preclinical |
| CHEMBL5266140 | 5.01 | IC50 | 9800.0 | Preclinical |
| CHEMBL5281023 | 4.82 | IC50 | 15200.0 | Preclinical |
| CHEMBL1537920 | 4.76 | IC50 | 17500.0 | Preclinical |
| CHEMBL1740905 | 4.7 | EC50 | 20000.0 | Preclinical |
| CHEMBL5280895 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL5272782 | 4.53 | IC50 | 29400.0 | Preclinical |
| CHEMBL1906834 | 4.32 | EC50 | 48000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 11 | 4.9 |