Insulin receptor substrate 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P35568. Use UniProt P35568 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P35568 as the stable identity anchor, then attach disease evidence before program review.
Insulin receptor substrate 1
Review this target as Insulin receptor substrate 1, mapped to UniProt P35568. Sequence length is 1242 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Insulin receptor substrate 1 as ChEMBL target CHEMBL4523219, mapped to UniProt P35568. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Insulin receptor substrate 1 is the right protein anchor across sources, using UniProt P35568 as the stable mapping.
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| Preferred Name | Insulin receptor substrate 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P35568 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Insulin receptor substrate 1 |
| UniProt Accession | P35568 |
| Component Type | Protein |
| Sequence Length | 1242 aa |
Insulin receptor substrate 1
Review this target as Insulin receptor substrate 1, mapped to UniProt P35568. Sequence length is 1242 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1681823 | 7.3 | Kd | 50.0 | Preclinical |
| CHEMBL1685056 | 7.3 | Kd | 50.0 | Preclinical |
| CHEMBL4536878 | 6.92 | Kd | 120.0 | Preclinical |
| CHEMBL1685055 | 6.82 | Kd | 150.0 | Preclinical |
| CHEMBL4530453 | 5.8 | Kd | 1600.0 | Preclinical |
| CHEMBL1572640 | 5.48 | Kd | 3300.0 | Preclinical |
| CHEMBL4576057 | 4.79 | Kd | 16400.0 | Preclinical |
| CHEMBL4591779 | 4.79 | Kd | 16200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 8 | 6.2 |
| cell-based format | 1 | 0 | — |