Utrophin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Utrophin shows clinical signal disease relevance led by Duchenne muscular dystrophy. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P46939. Start with Duchenne muscular dystrophy, then reuse UniProt P46939 as the stable protein anchor across project notes and exports.
Start with Duchenne muscular dystrophy, then reuse UniProt P46939 as the stable protein anchor across project notes and exports.
Utrophin shows clinical signal disease relevance led by Duchenne muscular dystrophy. 1 linked drug remains visible in the same block.
Start review with Duchenne muscular dystrophy because it currently carries clinical signal support. Linked drugs include EZUTROMID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyUtrophin
Review this target as Utrophin, mapped to UniProt P46939. Sequence length is 3433 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Utrophin as ChEMBL target CHEMBL4523230, mapped to UniProt P46939. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Utrophin is the right protein anchor across sources, using UniProt P46939 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Duchenne muscular dystrophy is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Utrophin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P46939 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Utrophin |
| UniProt Accession | P46939 |
| Component Type | Protein |
| Sequence Length | 3433 aa |
Utrophin
Review this target as Utrophin, mapped to UniProt P46939. Sequence length is 3433 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Utrophin shows clinical signal disease relevance led by Duchenne muscular dystrophy.
Start review with Duchenne muscular dystrophy because it currently carries clinical signal support. Linked drugs include EZUTROMID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4639067 | 8.4 | EC50 | 4.0 | Preclinical |
| CHEMBL4639832 | 8.0 | EC50 | 10.0 | Preclinical |
| CHEMBL4641041 | 7.58 | EC50 | 26.0 | Preclinical |
| CHEMBL4645628 | 7.47 | EC50 | 34.0 | Preclinical |
| CHEMBL4637833 | 7.42 | EC50 | 38.0 | Preclinical |
| CHEMBL4647136 | 7.21 | EC50 | 62.0 | Preclinical |
| CHEMBL4638445 | 7.15 | EC50 | 71.0 | Preclinical |
| CHEMBL4643175 | 7.15 | EC50 | 71.0 | Preclinical |
| CHEMBL4638708 | 7.07 | EC50 | 85.0 | Preclinical |
| CHEMBL4634557 | 6.97 | EC50 | 108.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 60 | 6.4 |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 5.5 |
| single protein format | 1 | 3 | 6.8 |