Glycine N-methyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q14749. Use UniProt Q14749 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14749 as the stable identity anchor, then attach disease evidence before program review.
Glycine N-methyltransferase
Review this target as Glycine N-methyltransferase, mapped to UniProt Q14749. Sequence length is 295 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glycine N-methyltransferase as ChEMBL target CHEMBL4523295, mapped to UniProt Q14749. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Glycine N-methyltransferase is the right protein anchor across sources, using UniProt Q14749 as the stable mapping.
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| Preferred Name | Glycine N-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14749 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glycine N-methyltransferase |
| UniProt Accession | Q14749 |
| Component Type | Protein |
| Sequence Length | 295 aa |
Glycine N-methyltransferase
Review this target as Glycine N-methyltransferase, mapped to UniProt Q14749. Sequence length is 295 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4874278 | 8.07 | IC50 | 8.6 | Preclinical |
| CHEMBL4850353 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL4875728 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL4869943 | 6.41 | IC50 | 390.0 | Preclinical |
| CHEMBL4849284 | 6.19 | IC50 | 640.0 | Preclinical |
| CHEMBL4870702 | 5.94 | IC50 | 1150.0 | Preclinical |
| CHEMBL4857500 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL4868791 | 5.57 | IC50 | 2700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 11 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 0 | — |