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Target Snapshot

CHEMBL4523309 Target Snapshot

Guanine nucleotide binding protein q polypeptide · SINGLE PROTEIN · Cricetulus griseus

2Compounds
1Assays
0Approved Drugs
2.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q3HR10. Use UniProt Q3HR10 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q3HR10 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Guanine nucleotide-binding protein subunit alpha

Guanine nucleotide-binding protein subunit alpha

Review this target as Guanine nucleotide binding protein q polypeptide, mapped to UniProt Q3HR10. ChEMBL maps the protein component as Guanine nucleotide-binding protein subunit alpha. Sequence length is 359 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q3HR10 Protein 359 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Guanine nucleotide binding protein q polypeptide as ChEMBL target CHEMBL4523309, mapped to UniProt Q3HR10. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Guanine nucleotide binding protein q polypeptide
SINGLE PROTEIN · Cricetulus griseus
As of 2026-09-14
ChEMBL target ID
CHEMBL4523309
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q3HR10
Guanine nucleotide-binding protein subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGuanine nucleotide-binding protein subunit alpha
UniProt AccessionQ3HR10
Component TypeProtein
Sequence Length359 aa

Guanine nucleotide-binding protein subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Guanine nucleotide binding protein q polypeptide, mapped to UniProt Q3HR10. ChEMBL maps the protein component as Guanine nucleotide-binding protein subunit alpha. Sequence length is 359 aa.

Mapped IDQ3HR10
Review nameGuanine nucleotide binding protein q polypeptide
OrganismCricetulus griseus
Assay Mix

Activity Type Distribution

IC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4171381 7.48 IC50 33.0 Preclinical
CHEMBL4288881 7.02 IC50 95.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
2
Tested Compounds
1
Assay Types
Binding — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 2 7.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine