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Target Snapshot

CHEMBL4523339 Target Snapshot

UDP-glucuronosyltransferase 1A1 · SINGLE PROTEIN · Rattus norvegicus

10Compounds
13Assays
1Approved Drugs
8.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q64550. Use UniProt Q64550 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q64550 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats UDP-glucuronosyltransferase 1A1 as ChEMBL target CHEMBL4523339, mapped to UniProt Q64550. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
UDP-glucuronosyltransferase 1A1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL4523339
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q64550
UDP-glucuronosyltransferase 1A1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether UDP-glucuronosyltransferase 1A1 is the right protein anchor across sources, using UniProt Q64550 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUDP-glucuronosyltransferase 1A1
UniProt AccessionQ64550
Component TypeProtein
Sequence Length535 aa

UDP-glucuronosyltransferase 1A1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as UDP-glucuronosyltransferase 1A1, mapped to UniProt Q64550. Sequence length is 535 aa.

Mapped IDQ64550
Review nameUDP-glucuronosyltransferase 1A1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC504.0
KI4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1163 5.47 IC50 3400.0 Approved
CHEMBL4573907 4.9 IC50 12600.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

13
Total Assays
4
Tested Compounds
1
Assay Types
ADME — 13 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0
microsome format 2 2 5.1
single protein format 2 2 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine