Methylcytosine dioxygenase TET2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q6N021. Use UniProt Q6N021 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6N021 as the stable identity anchor, then attach disease evidence before program review.
Methylcytosine dioxygenase TET2
Review this target as Methylcytosine dioxygenase TET2, mapped to UniProt Q6N021. Sequence length is 2002 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Methylcytosine dioxygenase TET2 as ChEMBL target CHEMBL4523344, mapped to UniProt Q6N021. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Methylcytosine dioxygenase TET2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6N021 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Methylcytosine dioxygenase TET2 |
| UniProt Accession | Q6N021 |
| Component Type | Protein |
| Sequence Length | 2002 aa |
Methylcytosine dioxygenase TET2
Review this target as Methylcytosine dioxygenase TET2, mapped to UniProt Q6N021. Sequence length is 2002 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5527999 | 6.91 | IC50 | 123.03 | Preclinical |
| CHEMBL5565375 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL4851104 | 6.52 | Kd | 300.0 | Preclinical |
| CHEMBL3785455 | 6.45 | IC50 | 354.81 | Preclinical |
| CHEMBL1230640 | 6.26 | IC50 | 549.54 | Preclinical |
| CHEMBL4855677 | 6.21 | Kd | 610.0 | Preclinical |
| CHEMBL5561497 | 6.08 | IC50 | 831.76 | Preclinical |
| CHEMBL5562105 | 6.03 | IC50 | 933.25 | Preclinical |
| CHEMBL5532540 | 5.95 | IC50 | 1122.02 | Preclinical |
| CHEMBL4872206 | 5.92 | IC50 | 1200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 9 | 45 | 5.2 |
| cell-based format | 8 | 16 | 5.0 |
| single protein format | 6 | 6 | 5.7 |