Cytochrome P450 4Z1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt Q86W10. Use UniProt Q86W10 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q86W10 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 4Z1
Review this target as Cytochrome P450 4Z1, mapped to UniProt Q86W10. Sequence length is 505 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 4Z1 as ChEMBL target CHEMBL4523375, mapped to UniProt Q86W10. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cytochrome P450 4Z1 is the right protein anchor across sources, using UniProt Q86W10 as the stable mapping.
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| Preferred Name | Cytochrome P450 4Z1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q86W10 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 4Z1 |
| UniProt Accession | Q86W10 |
| Component Type | Protein |
| Sequence Length | 505 aa |
Cytochrome P450 4Z1
Review this target as Cytochrome P450 4Z1, mapped to UniProt Q86W10. Sequence length is 505 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5272822 | 7.38 | IC50 | 41.8 | Preclinical |
| CHEMBL4800099 | 7.2 | IC50 | 63.0 | Preclinical |
| CHEMBL5267609 | 7.05 | IC50 | 89.7 | Preclinical |
| CHEMBL4564920 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL5274921 | 6.96 | IC50 | 108.9 | Preclinical |
| CHEMBL4557940 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL4590991 | 6.7 | IC50 | 200.0 | Preclinical |
| CHEMBL4435658 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL4447108 | 6.4 | IC50 | 400.0 | Preclinical |
| CHEMBL4466562 | 6.3 | IC50 | 500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 33 | 12 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 5 | 6.8 |