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Target Snapshot

CHEMBL4523390 Target Snapshot

Plasmepsin X · SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)

46Compounds
10Assays
0Approved Drugs
45.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8IAS0. Use UniProt Q8IAS0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8IAS0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Plasmepsin X as ChEMBL target CHEMBL4523390, mapped to UniProt Q8IAS0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Plasmepsin X
SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)
As of 2026-09-14
ChEMBL target ID
CHEMBL4523390
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8IAS0
Plasmepsin X
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Plasmepsin X is the right protein anchor across sources, using UniProt Q8IAS0 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPlasmepsin X
UniProt AccessionQ8IAS0
Component TypeProtein
Sequence Length573 aa

Plasmepsin X

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Plasmepsin X, mapped to UniProt Q8IAS0. Sequence length is 573 aa.

Mapped IDQ8IAS0
Review namePlasmepsin X
OrganismPlasmodium falciparum (isolate 3D7)
Assay Mix

Activity Type Distribution

IC5045.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5171401 10.52 IC50 0.03 Preclinical
CHEMBL5182418 10.22 IC50 0.06 Preclinical
CHEMBL5187792 10.15 IC50 0.07 Preclinical
CHEMBL5193119 9.52 IC50 0.3 Preclinical
CHEMBL5199100 9.4 IC50 0.4 Preclinical
CHEMBL5410627 9.4 IC50 0.4 Preclinical
CHEMBL5207556 9.22 IC50 0.6 Preclinical
CHEMBL5197877 8.72 IC50 1.9 Preclinical
CHEMBL5411166 8.6 IC50 2.5 Preclinical
CHEMBL5427012 8.42 IC50 3.8 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
0
6.0
1
6.5
2
7.0
12
7.5
20
8.0
2
8.5
3
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

10
Total Assays
44
Tested Compounds
1
Assay Types
Binding — 10 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 9 38 8.3
cell-based format 1 6 7.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine