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Evidence Snapshot

Prolyl 3-hydroxylase OGFOD1

CHEMBL4523398 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:30:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4523398
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prolyl 3-hydroxylase OGFOD1 as ChEMBL target CHEMBL4523398, mapped to UniProt Q8N543. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prolyl 3-hydroxylase OGFOD1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523398
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8N543
Prolyl 3-hydroxylase OGFOD1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Prolyl 3-hydroxylase OGFOD1 matters

As of 2026-09-13

Prolyl 3-hydroxylase OGFOD1 is reviewed as Prolyl 3-hydroxylase OGFOD1 (UniProt Q8N543); the current evidence base includes 1 approved drug, 5 compounds, and 1 assay, with lead potency reaching pChEMBL 5.8.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 5 compounds, and 1 assay for this target. The dominant activity type is IC50. CHEMBL3646221 is the current potency anchor at pChEMBL 5.8.

Use CHEMBL3646221 as the tractability anchor when discussing potency (pChEMBL 5.8).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 5.8
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Prolyl 3-hydroxylase OGFOD1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q8N543, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

5
Total Compounds
1
Total Assays
1
Approved Drugs
IC50: 5.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3646221
 5.8 IC50 Approved
No preferred name
CHEMBL4163812
 5.7 IC50 —
No preferred name
CHEMBL3646117
 5.3 IC50 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:30:04Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4523398