Methylcytosine dioxygenase TET1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q8NFU7. Use UniProt Q8NFU7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8NFU7 as the stable identity anchor, then attach disease evidence before program review.
Methylcytosine dioxygenase TET1
Review this target as Methylcytosine dioxygenase TET1, mapped to UniProt Q8NFU7. Sequence length is 2136 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Methylcytosine dioxygenase TET1 as ChEMBL target CHEMBL4523402, mapped to UniProt Q8NFU7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Methylcytosine dioxygenase TET1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q8NFU7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Methylcytosine dioxygenase TET1 |
| UniProt Accession | Q8NFU7 |
| Component Type | Protein |
| Sequence Length | 2136 aa |
Methylcytosine dioxygenase TET1
Review this target as Methylcytosine dioxygenase TET1, mapped to UniProt Q8NFU7. Sequence length is 2136 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5527999 | 7.74 | IC50 | 18.2 | Preclinical |
| CHEMBL5557793 | 6.76 | IC50 | 173.78 | Preclinical |
| CHEMBL5559263 | 6.71 | IC50 | 194.98 | Preclinical |
| CHEMBL5549950 | 6.69 | IC50 | 204.17 | Preclinical |
| CHEMBL5532540 | 6.62 | IC50 | 239.88 | Preclinical |
| CHEMBL5565375 | 6.6 | IC50 | 250.0 | Preclinical |
| CHEMBL3785455 | 6.6 | IC50 | 251.19 | Preclinical |
| CHEMBL5557372 | 6.59 | IC50 | 257.04 | Preclinical |
| CHEMBL5557587 | 6.57 | IC50 | 269.15 | Preclinical |
| CHEMBL5561497 | 6.44 | IC50 | 363.08 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 17 | 63 | 5.5 |
| single protein format | 11 | 2 | 5.0 |