Use UniProt Q9UHH9 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4523488 Target Snapshot
Inositol hexakisphosphate kinase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9UHH9. Use UniProt Q9UHH9 as the stable identity anchor, then attach disease evidence before program review.
Inositol hexakisphosphate kinase 2
Review this target as Inositol hexakisphosphate kinase 2, mapped to UniProt Q9UHH9. Sequence length is 426 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Inositol hexakisphosphate kinase 2 as ChEMBL target CHEMBL4523488, mapped to UniProt Q9UHH9. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Inositol hexakisphosphate kinase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UHH9 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Inositol hexakisphosphate kinase 2 |
| UniProt Accession | Q9UHH9 |
| Component Type | Protein |
| Sequence Length | 426 aa |
Inositol hexakisphosphate kinase 2
How to read this target
Review this target as Inositol hexakisphosphate kinase 2, mapped to UniProt Q9UHH9. Sequence length is 426 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5190343 | 8.31 | IC50 | 4.9 | Preclinical |
| CHEMBL5203174 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL5169462 | 7.27 | IC50 | 54.0 | Preclinical |
| CHEMBL5186210 | 7.19 | IC50 | 65.0 | Preclinical |
| CHEMBL5200214 | 7.15 | IC50 | 71.0 | Preclinical |
| CHEMBL5181623 | 7.13 | IC50 | 74.0 | Preclinical |
| CHEMBL5190343 | 7.13 | Kd | 74.0 | Preclinical |
| CHEMBL5184960 | 7.03 | IC50 | 94.0 | Preclinical |
| CHEMBL5204881 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL5184940 | 6.89 | IC50 | 130.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 16 assays, 60 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 8 | 37 | 6.3 |
| single protein format | 6 | 23 | 5.3 |
| cell-based format | 2 | 0 | — |