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Target Snapshot

CHEMBL4523488 Target Snapshot

Inositol hexakisphosphate kinase 2 · SINGLE PROTEIN · Homo sapiens

66Compounds
16Assays
0Approved Drugs
69.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q9UHH9. Use UniProt Q9UHH9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UHH9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Inositol hexakisphosphate kinase 2 as ChEMBL target CHEMBL4523488, mapped to UniProt Q9UHH9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Inositol hexakisphosphate kinase 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523488
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9UHH9
Inositol hexakisphosphate kinase 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Inositol hexakisphosphate kinase 2 is the right protein anchor across sources, using UniProt Q9UHH9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInositol hexakisphosphate kinase 2
UniProt AccessionQ9UHH9
Component TypeProtein
Sequence Length426 aa

Inositol hexakisphosphate kinase 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Inositol hexakisphosphate kinase 2, mapped to UniProt Q9UHH9. Sequence length is 426 aa.

Mapped IDQ9UHH9
Review nameInositol hexakisphosphate kinase 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5067.0
KI1.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5190343 8.31 IC50 4.9 Preclinical
CHEMBL5203174 7.6 IC50 25.0 Preclinical
CHEMBL5169462 7.27 IC50 54.0 Preclinical
CHEMBL5186210 7.19 IC50 65.0 Preclinical
CHEMBL5200214 7.15 IC50 71.0 Preclinical
CHEMBL5181623 7.13 IC50 74.0 Preclinical
CHEMBL5190343 7.13 Kd 74.0 Preclinical
CHEMBL5184960 7.03 IC50 94.0 Preclinical
CHEMBL5204881 7.0 IC50 100.0 Preclinical
CHEMBL5184940 6.89 IC50 130.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
9
5.5
14
6.0
10
6.5
8
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

16
Total Assays
60
Tested Compounds
1
Assay Types
Binding — 16 assays, 60 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 8 37 6.3
single protein format 6 23 5.3
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine