Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4523517 Target Snapshot

NAD-dependent protein deacetylase · SINGLE PROTEIN · Schistosoma mansoni

55Compounds
37Assays
2Approved Drugs
19.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt T1VXA1. Use UniProt T1VXA1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt T1VXA1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NAD-dependent protein deacetylase as ChEMBL target CHEMBL4523517, mapped to UniProt T1VXA1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NAD-dependent protein deacetylase
SINGLE PROTEIN · Schistosoma mansoni
As of 2026-09-14
ChEMBL target ID
CHEMBL4523517
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
T1VXA1
NAD-dependent protein deacetylase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NAD-dependent protein deacetylase is the right protein anchor across sources, using UniProt T1VXA1 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNAD-dependent protein deacetylase
UniProt AccessionT1VXA1
Component TypeProtein
Sequence Length337 aa

NAD-dependent protein deacetylase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as NAD-dependent protein deacetylase, mapped to UniProt T1VXA1. Sequence length is 337 aa.

Mapped IDT1VXA1
Review nameNAD-dependent protein deacetylase
OrganismSchistosoma mansoni
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL252556 5.72 IC50 1900.0 Approved
CHEMBL4444104 5.7 IC50 2000.0 Preclinical
CHEMBL4442390 5.63 IC50 2340.0 Preclinical
CHEMBL4567519 5.48 IC50 3300.0 Preclinical
CHEMBL4461910 5.37 IC50 4300.0 Preclinical
CHEMBL4577629 4.9 IC50 12500.0 Preclinical
CHEMBL4459211 4.89 IC50 12800.0 Preclinical
CHEMBL3431191 4.85 IC50 14000.0 Preclinical
CHEMBL4526249 4.83 IC50 14900.0 Preclinical
CHEMBL3431127 4.78 IC50 16800.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
3
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

37
Total Assays
17
Tested Compounds
2
Assay Types
ADME — 21 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 0
Binding — 16 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 17 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine