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Target Snapshot

CHEMBL4523575 Target Snapshot

HCC4006 · CELL-LINE · Homo sapiens

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28Compounds
12Assays
2Approved Drugs
13.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCC4006 as ChEMBL target CHEMBL4523575. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCC4006
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523575
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HCC4006 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHCC4006
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHCC4006
UniProt AccessionN/A

HCC4006

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HCC4006.

Review nameHCC4006
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5012.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3128043 8.42 IC50 3.79 Preclinical
CHEMBL4225519 8.41 IC50 3.9 Preclinical
CHEMBL2110732 8.4 IC50 4.0 Approved
CHEMBL4228472 7.96 IC50 11.0 Preclinical
CHEMBL939 7.3 IC50 50.0 Approved
CHEMBL3901808 6.33 IC50 470.0 Preclinical
CHEMBL5268484 5.7 IC50 2000.0 Preclinical
CHEMBL4282264 5.33 EC50 4640.0 Preclinical
CHEMBL5270178 4.7 IC50 20000.0 Preclinical
CHEMBL5282240 4.7 IC50 20000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
2
6.0
0
6.5
1
7.0
1
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DACOMITINIB ANHYDROUS
CHEMBL2110732
Approved 2018
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
10
Tested Compounds
1
Assay Types
Functional — 12 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 10 6.7
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine