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Target Snapshot

CHEMBL4523576 Target Snapshot

OCI-AML-5 · CELL-LINE · Homo sapiens

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20Compounds
14Assays
3Approved Drugs
16.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats OCI-AML-5 as ChEMBL target CHEMBL4523576. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
OCI-AML-5
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523576
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether OCI-AML-5 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameOCI-AML-5
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOCI-AML-5
UniProt AccessionN/A

OCI-AML-5

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as OCI-AML-5.

Review nameOCI-AML-5
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5012.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4765060 9.8 IC50 0.159 Preclinical
CHEMBL4790597 9.8 IC50 0.159 Preclinical
CHEMBL4439276 8.4 IC50 4.0 Preclinical
CHEMBL535 7.85 IC50 14.0 Approved
CHEMBL576982 7.52 IC50 30.0 Approved
CHEMBL3137309 6.96 EC50 110.0 Approved
CHEMBL443684 6.75 EC50 180.0 Clinical
CHEMBL5268484 5.7 IC50 2000.0 Preclinical
CHEMBL4282264 5.31 EC50 4860.0 Preclinical
CHEMBL5270178 4.7 IC50 20000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
0
6.0
2
6.5
0
7.0
2
7.5
1
8.0
0
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

QUIZARTINIB
CHEMBL576982
Approved 2023
Properties Compare Identifier
VENETOCLAX
CHEMBL3137309
Approved 2016
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

14
Total Assays
14
Tested Compounds
1
Assay Types
Functional — 14 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 14 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine