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Target Snapshot

CHEMBL4523585 Target Snapshot

Genome polyprotein · SINGLE PROTEIN · Yellow fever virus (strain 17D vaccine) (YFV)

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Genome polyprotein shows clinical signal disease relevance led by COVID-19. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P03314. Start with COVID-19, then reuse UniProt P03314 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with COVID-19, then reuse UniProt P03314 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
COVID-19

Genome polyprotein shows clinical signal disease relevance led by COVID-19. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include GALIDESIVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Genome polyprotein as ChEMBL target CHEMBL4523585, mapped to UniProt P03314. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Genome polyprotein
SINGLE PROTEIN · Yellow fever virus (strain 17D vaccine) (YFV)
As of 2026-09-14
ChEMBL target ID
CHEMBL4523585
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P03314
Genome polyprotein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Genome polyprotein is the right protein anchor across sources, using UniProt P03314 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why COVID-19 is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGenome polyprotein
UniProt AccessionP03314
Component TypeProtein
Sequence Length3411 aa

Genome polyprotein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Genome polyprotein, mapped to UniProt P03314. Sequence length is 3411 aa.

Mapped IDP03314
Review nameGenome polyprotein
OrganismYellow fever virus (strain 17D vaccine) (YFV)
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Genome polyprotein shows clinical signal disease relevance led by COVID-19. 2 more disease programs remain visible in the same review block.

Clinical signal Phase I
COVID-19
1 linked drug · 1 direct · 1 efficacy
Linked drugGALIDESIVIR
Clinical signal Phase I
Fever
1 linked drug · 1 direct · 1 efficacy
Linked drugGALIDESIVIR
Clinical signal Phase I
Marburg hemorrhagic fever
1 linked drug · 1 direct · 1 efficacy
Linked drugGALIDESIVIR
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with COVID-19 because it currently carries clinical signal support. Linked drugs include GALIDESIVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseCOVID-19
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine