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Target Snapshot

CHEMBL4523587 Target Snapshot

Tumor necrosis factor receptor superfamily member 17 · SINGLE PROTEIN · Homo sapiens

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Tumor necrosis factor receptor superfamily member 17 shows approved-linked disease relevance led by multiple myeloma. 5 more disease programs remain visible in the same review block. 5 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q02223. Start with multiple myeloma, then reuse UniProt Q02223 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with multiple myeloma, then reuse UniProt Q02223 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 5 linked drugs
Open source guide
Disease program
multiple myeloma

Tumor necrosis factor receptor superfamily member 17 shows approved-linked disease relevance led by multiple myeloma. 5 more disease programs remain visible in the same review block. 5 linked drugs remain visible in the same block.

Start review with multiple myeloma because it currently carries approved-linked support. Linked drugs include BELANTAMAB MAFODOTIN, CILTACABTAGENE AUTOLEUCEL, ELRANATAMAB, IDECABTAGENE VICLEUCEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 5 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tumor necrosis factor receptor superfamily member 17 as ChEMBL target CHEMBL4523587, mapped to UniProt Q02223. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tumor necrosis factor receptor superfamily member 17
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523587
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q02223
Tumor necrosis factor receptor superfamily member 17
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Tumor necrosis factor receptor superfamily member 17 is the right protein anchor across sources, using UniProt Q02223 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why multiple myeloma is currently framed as approved-linked support. It currently carries 5 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTumor necrosis factor receptor superfamily member 17
UniProt AccessionQ02223
Component TypeProtein
Sequence Length184 aa

Tumor necrosis factor receptor superfamily member 17

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Tumor necrosis factor receptor superfamily member 17, mapped to UniProt Q02223. Sequence length is 184 aa.

Mapped IDQ02223
Review nameTumor necrosis factor receptor superfamily member 17
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Tumor necrosis factor receptor superfamily member 17 shows approved-linked disease relevance led by multiple myeloma. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
multiple myeloma
5 linked drugs · 5 direct · 5 efficacy
Linked drugBELANTAMAB MAFODOTIN
Linked drugCILTACABTAGENE AUTOLEUCEL
Linked drugELRANATAMAB
Linked drugIDECABTAGENE VICLEUCEL
Approved-linked Approved
neoplasm
4 linked drugs · 4 direct · 4 efficacy
Linked drugBELANTAMAB MAFODOTIN
Linked drugELRANATAMAB
Linked drugIDECABTAGENE VICLEUCEL
Linked drugTECLISTAMAB
Approved-linked Approved
Abnormality of blood and blood-forming tissues
1 linked drug · 1 direct · 1 efficacy
Linked drugIDECABTAGENE VICLEUCEL
Approved-linked Approved
blood disease
1 linked drug · 1 direct · 1 efficacy
Linked drugIDECABTAGENE VICLEUCEL
Approved-linked Approved
cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugTECLISTAMAB
Approved-linked Approved
cardiovascular disease
1 linked drug · 1 direct · 1 efficacy
Linked drugIDECABTAGENE VICLEUCEL
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with multiple myeloma because it currently carries approved-linked support. Linked drugs include BELANTAMAB MAFODOTIN, CILTACABTAGENE AUTOLEUCEL, ELRANATAMAB, IDECABTAGENE VICLEUCEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasemultiple myeloma
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine