Prkaa1/Prkab2/Prkag1 · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P54645. Use UniProt P54645 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54645 as the stable identity anchor, then attach disease evidence before program review.
5'-AMP-activated protein kinase catalytic subunit alpha-1
Review this target as Prkaa1/Prkab2/Prkag1, mapped to UniProt P54645. ChEMBL maps the protein component as 5'-AMP-activated protein kinase catalytic subunit alpha-1. Sequence length is 559 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prkaa1/Prkab2/Prkag1 as ChEMBL target CHEMBL4523617, mapped to UniProt P54645. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Prkaa1/Prkab2/Prkag1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P54645 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
| UniProt Accession | P54645 |
| Component Type | Protein |
| Sequence Length | 559 aa |
5'-AMP-activated protein kinase catalytic subunit alpha-1
Review this target as Prkaa1/Prkab2/Prkag1, mapped to UniProt P54645. ChEMBL maps the protein component as 5'-AMP-activated protein kinase catalytic subunit alpha-1. Sequence length is 559 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4167177 | 8.12 | EC50 | 7.5 | Preclinical |
| CHEMBL4082745 | 7.4 | EC50 | 40.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 7.8 |