PDE5A/PDE6C · CHIMERIC PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O76074. Use UniProt O76074 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O76074 as the stable identity anchor, then attach disease evidence before program review.
cGMP-specific 3',5'-cyclic phosphodiesterase
Review this target as PDE5A/PDE6C, mapped to UniProt O76074. ChEMBL maps the protein component as cGMP-specific 3',5'-cyclic phosphodiesterase. Sequence length is 875 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats PDE5A/PDE6C as ChEMBL target CHEMBL4523626, mapped to UniProt O76074. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether PDE5A/PDE6C is the right protein anchor across sources, using UniProt O76074 as the stable mapping.
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| Preferred Name | PDE5A/PDE6C |
| Target Type | CHIMERIC PROTEIN |
| Organism | Homo sapiens |
| UniProt | O76074 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | cGMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Accession | O76074 |
| Component Type | Protein |
| Sequence Length | 875 aa |
cGMP-specific 3',5'-cyclic phosphodiesterase
Review this target as PDE5A/PDE6C, mapped to UniProt O76074. ChEMBL maps the protein component as cGMP-specific 3',5'-cyclic phosphodiesterase. Sequence length is 875 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL192 | 7.6 | Ki | 25.0 | Approved |
| CHEMBL275084 | 5.07 | Ki | 8500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 6.3 |