IDH1/IDH2 · PROTEIN FAMILY · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13IDH1/IDH2 shows approved-linked disease relevance led by Astrocytoma. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O75874. Start with Astrocytoma, then reuse UniProt O75874 as the stable protein anchor across project notes and exports.
Start with Astrocytoma, then reuse UniProt O75874 as the stable protein anchor across project notes and exports.
IDH1/IDH2 shows approved-linked disease relevance led by Astrocytoma. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Astrocytoma because it currently carries approved-linked support. Linked drugs include VORASIDENIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyIsocitrate dehydrogenase [NADP] cytoplasmic
Review this target as IDH1/IDH2, mapped to UniProt O75874. ChEMBL maps the protein component as Isocitrate dehydrogenase [NADP] cytoplasmic. Sequence length is 414 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats IDH1/IDH2 as ChEMBL target CHEMBL4523659, mapped to UniProt O75874. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether IDH1/IDH2 is the right protein anchor across sources, using UniProt O75874 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Astrocytoma is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | IDH1/IDH2 |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | O75874 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Isocitrate dehydrogenase [NADP] cytoplasmic |
| UniProt Accession | O75874 |
| Component Type | Protein |
| Sequence Length | 414 aa |
Isocitrate dehydrogenase [NADP] cytoplasmic
Review this target as IDH1/IDH2, mapped to UniProt O75874. ChEMBL maps the protein component as Isocitrate dehydrogenase [NADP] cytoplasmic. Sequence length is 414 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
IDH1/IDH2 shows approved-linked disease relevance led by Astrocytoma. 5 more disease programs remain visible in the same review block.
Start review with Astrocytoma because it currently carries approved-linked support. Linked drugs include VORASIDENIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |