von Hippel-Lindau disease tumor suppressor/IRAK4 · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NWZ3. Use UniProt Q9NWZ3 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NWZ3 as the stable identity anchor, then attach disease evidence before program review.
Interleukin-1 receptor-associated kinase 4
Review this target as von Hippel-Lindau disease tumor suppressor/IRAK4, mapped to UniProt Q9NWZ3. ChEMBL maps the protein component as Interleukin-1 receptor-associated kinase 4. Sequence length is 460 aa.
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This review treats von Hippel-Lindau disease tumor suppressor/IRAK4 as ChEMBL target CHEMBL4523742, mapped to UniProt Q9NWZ3. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | von Hippel-Lindau disease tumor suppressor/IRAK4 |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | Q9NWZ3 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-1 receptor-associated kinase 4 |
| UniProt Accession | Q9NWZ3 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Interleukin-1 receptor-associated kinase 4
Review this target as von Hippel-Lindau disease tumor suppressor/IRAK4, mapped to UniProt Q9NWZ3. ChEMBL maps the protein component as Interleukin-1 receptor-associated kinase 4. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4081711 | 7.8 | IC50 | 15.85 | Clinical |
| CHEMBL4521789 | 7.5 | IC50 | 31.62 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 17 | 2 | 7.4 |
| cell-based format | 5 | 0 | — |