Dihydroorotate dehydrogenase (quinone), mitochondrial · SINGLE PROTEIN · Schistosoma mansoni
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As of 2026-09-14Protein identity stays anchored to UniProt G4VFD7. Use UniProt G4VFD7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt G4VFD7 as the stable identity anchor, then attach disease evidence before program review.
Dihydroorotate dehydrogenase (quinone), mitochondrial
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt G4VFD7. Sequence length is 379 aa.
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This review treats Dihydroorotate dehydrogenase (quinone), mitochondrial as ChEMBL target CHEMBL4523950, mapped to UniProt G4VFD7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
| UniProt | G4VFD7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydroorotate dehydrogenase (quinone), mitochondrial |
| UniProt Accession | G4VFD7 |
| Component Type | Protein |
| Sequence Length | 379 aa |
Dihydroorotate dehydrogenase (quinone), mitochondrial
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt G4VFD7. Sequence length is 379 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL15193 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL4540838 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL155771 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4452960 | 7.11 | IC50 | 78.0 | Preclinical |
| CHEMBL4472078 | 6.96 | IC50 | 111.0 | Preclinical |
| CHEMBL4457147 | 6.89 | IC50 | 129.0 | Preclinical |
| CHEMBL4560384 | 6.73 | IC50 | 185.0 | Preclinical |
| CHEMBL4474026 | 6.64 | IC50 | 227.0 | Preclinical |
| CHEMBL4527976 | 6.43 | IC50 | 375.0 | Preclinical |
| CHEMBL1450 | 6.37 | IC50 | 430.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 29 | 5.8 |