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Target Snapshot

CHEMBL4523999 Target Snapshot

mTORC2 · PROTEIN COMPLEX · Homo sapiens

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192Compounds
92Assays
0Approved Drugs
161.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P42345. Use UniProt P42345 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P42345 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats mTORC2 as ChEMBL target CHEMBL4523999, mapped to UniProt P42345. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
mTORC2
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4523999
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P42345
Serine/threonine-protein kinase mTOR
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether mTORC2 is the right protein anchor across sources, using UniProt P42345 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamemTORC2
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP42345
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase mTOR
UniProt AccessionP42345
Component TypeProtein
Sequence Length2549 aa

Serine/threonine-protein kinase mTOR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as mTORC2, mapped to UniProt P42345. ChEMBL maps the protein component as Serine/threonine-protein kinase mTOR. Sequence length is 2549 aa.

Mapped IDP42345
Review namemTORC2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50158.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1236962 9.74 IC50 0.18 Clinical
CHEMBL1236962 9.52 Ki 0.3 Clinical
CHEMBL4563142 9.0 IC50 1.0 Preclinical
CHEMBL5219718 9.0 IC50 1.0 Preclinical
CHEMBL5218727 8.96 IC50 1.1 Preclinical
CHEMBL5218916 8.92 IC50 1.2 Preclinical
CHEMBL5219710 8.82 IC50 1.5 Preclinical
CHEMBL1256459 8.7 IC50 2.0 Preclinical
CHEMBL5218988 8.66 IC50 2.2 Preclinical
CHEMBL5220152 8.62 IC50 2.4 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
7
5.5
19
6.0
19
6.5
33
7.0
15
7.5
13
8.0
10
8.5
2
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

92
Total Assays
119
Tested Compounds
1
Assay Types
Binding — 92 assays, 119 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 79 95 7.2
protein complex format 12 23 7.5
assay format 1 1 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine