5'-AMP-activated protein kinase · PROTEIN FAMILY · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q5EG47. Use UniProt Q5EG47 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q5EG47 as the stable identity anchor, then attach disease evidence before program review.
5'-AMP-activated protein kinase catalytic subunit alpha-1
Review this target as 5'-AMP-activated protein kinase, mapped to UniProt Q5EG47. ChEMBL maps the protein component as 5'-AMP-activated protein kinase catalytic subunit alpha-1. Sequence length is 559 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5'-AMP-activated protein kinase as ChEMBL target CHEMBL4524004, mapped to UniProt Q5EG47. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 5'-AMP-activated protein kinase |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q5EG47 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
| UniProt Accession | Q5EG47 |
| Component Type | Protein |
| Sequence Length | 559 aa |
5'-AMP-activated protein kinase catalytic subunit alpha-1
Review this target as 5'-AMP-activated protein kinase, mapped to UniProt Q5EG47. ChEMBL maps the protein component as 5'-AMP-activated protein kinase catalytic subunit alpha-1. Sequence length is 559 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4167177 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL5423513 | 8.05 | EC50 | 9.0 | Preclinical |
| CHEMBL5416891 | 7.57 | EC50 | 27.0 | Preclinical |
| CHEMBL5416830 | 7.55 | EC50 | 28.0 | Preclinical |
| CHEMBL5437756 | 7.3 | EC50 | 50.0 | Preclinical |
| CHEMBL5424079 | 7.09 | EC50 | 82.0 | Preclinical |
| CHEMBL5406700 | 7.08 | EC50 | 84.0 | Preclinical |
| CHEMBL5412549 | 7.06 | EC50 | 87.0 | Preclinical |
| CHEMBL5398580 | 6.96 | EC50 | 110.0 | Preclinical |
| CHEMBL3393137 | 6.86 | EC50 | 137.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 31 | 17 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 2 | 0 | — |